McAfee J G, Thomas F D, Roskopf M, Ritter K, Lyons B, Lilien O M, Schoonmaker J E
Invest Radiol. 1984 Nov-Dec;19(6):543-8. doi: 10.1097/00004424-198411000-00013.
A pyridoxine (vitamin B6)-deficient diet in rats was used as a model of early renal lithiasis to find out if "stone-formers" could be identified from control animals by differences in the biodistribution of Tc-99m MDP. The mean renal uptake of this agent at 3 hours was about 70% higher in test animals than in controls, but there was considerable overlap between the upper limits of the normal range and lower values in "stone-formers." If these results were valid for humans, the metabolic abnormality in males with early stone-forming disease could not be identified with certainty by in vivo measurements of Tc-99m MDP renal uptake alone. However, the skeletal uptake of MDP in the "stone-forming" animals was depressed by 28 to 35%, compared with control rats. Consequently, the renal to skeletal MDP concentration ratio was invariably elevated in "stone-formers" beyond the 95 percentile normal range. Unexpectedly, 76% of the pyridoxine-deficient animals had a higher accumulation of MDP in the myocardium than the upper limit of the normal range. The pyridoxine-deficient diet induced no remarkable early changes in the biodistribution or renal clearance of I-131 Hippuran.
在大鼠中，使用缺乏吡哆醇（维生素B6）的饮食作为早期肾结石形成的模型，以确定是否可以通过Tc-99m MDP生物分布的差异从对照动物中识别出“结石形成者”。在3小时时，该试剂在试验动物中的平均肾脏摄取量比对照动物高约70%，但正常范围的上限与“结石形成者”的较低值之间存在相当大的重叠。如果这些结果对人类有效，仅通过体内测量Tc-99m MDP的肾脏摄取量，无法确定患有早期结石形成疾病男性的代谢异常。然而，与对照大鼠相比，“结石形成”动物中MDP的骨骼摄取量降低了28%至35%。因此，“结石形成者”中肾脏与骨骼MDP浓度比始终高于正常范围的第95百分位数。出乎意料的是，76%的缺乏吡哆醇的动物心肌中MDP的积累高于正常范围的上限。缺乏吡哆醇的饮食对I-131马尿酸的生物分布或肾脏清除率没有引起明显的早期变化。
