Reid W O, Henry R L, MacPherson B, Hellerman D V, Urwiller K L
Med Hypotheses. 1984 Oct;15(2):169-83. doi: 10.1016/0306-9877(84)90123-3.
The balance concept between the procoagulant and inhibitor systems allows a perspective to better diagnose opposite hemostatic mechanisms, especially hemorrhagic tendencies as a result of intravascular consumption coagulopathy from pathologic fibrinolysis. Concepts presented are intended to provide a base for following the ever changing patient therapeutic response in the course of these sometimes fulminant conditions. A concise description of the Serial Thrombin Time test (STT) is presented as a rapid quantitative test for the differentiation of opposing mechanisms affecting hemostasis. Typical patient cases are presented to demonstrate the use of the STT in diagnosis, selection of therapeutic agents, and management of hemorrhagic episodes. Presented are cases of disseminated intravascular coagulation, primary fibrinolysis, coronary thrombosis, and hemophilia.
促凝血系统和抑制系统之间的平衡概念为更好地诊断相反的止血机制提供了一个视角，尤其是因病理性纤维蛋白溶解导致的血管内消耗性凝血病引起的出血倾向。所提出的概念旨在为在这些有时会迅速发展的病症过程中跟踪患者不断变化的治疗反应提供一个基础。本文简要描述了连续凝血酶时间试验（STT），它是一种用于区分影响止血的相反机制的快速定量试验。文中给出了典型的患者病例，以说明STT在诊断、治疗药物选择和出血事件管理中的应用。文中介绍了弥散性血管内凝血、原发性纤维蛋白溶解、冠状动脉血栓形成和血友病的病例。
