Bhatt S D, Bora P S
Indian J Physiol Pharmacol. 1984 Jul-Sep;28(3):200-5.
Blood glucose variations and concomitant bioptical cytopathological changes in the pancreatic islets following treatment with certain drugs were studied in the catfish. Glucose loading produced a dose-related hyperglycemia, maximum within 3 hr, while alloxan caused a biphasic rise in glucose level without induction of permanent diabetes. Streptozotocin elicited a monophasic hyperglycemic state at a lower dose and biphasic response at higher doses. Glybenclamide produced hypoglycemia in normal and sham-operated fish; the depancreatized animals were unresponsive to this treatment. In all the cases, normoglycemic values were restituted within 4 days of the treatment. The beta-cells of the islets underwent varying histopathological changes with signs of regenerative activity. A depletion in heavy metal (zinc) in these cells was also evident after treatment with streptozotocin.
研究了鲶鱼在使用某些药物治疗后血糖变化以及胰岛伴随的活检细胞病理学变化。葡萄糖负荷导致剂量相关的高血糖，在3小时内达到最大值，而四氧嘧啶引起血糖水平双相升高，但未诱发永久性糖尿病。链脲佐菌素在较低剂量时引起单相高血糖状态，在较高剂量时引起双相反应。格列本脲在正常和假手术鱼中产生低血糖；胰腺切除的动物对这种治疗无反应。在所有情况下，治疗后4天内血糖值恢复正常。胰岛的β细胞经历了不同的组织病理学变化，并有再生活动的迹象。用链脲佐菌素治疗后，这些细胞中的重金属（锌）也明显减少。
