Bogush N L, Leskov V P, Mazharov M K, Prozorovskiĭ N S, Serov A A
Ter Arkh. 1984;56(11):109-14.
The total IgE level and some indicators of nonspecific suppressor activity (NSA) (the amount of theophylline-sensitive sells and the activity of Con A-induced spontaneous and short-lived suppressors) were studied in 36 pollinosis patients with high sensitivity to timothy dust, confirmed by the data of the allergological anamnesis, the data of skin and provocative tests with timothy allergen, and by the presence of allergen-specific IgE antibodies. The IgE level ranged from 23 to 2925 KU/1. Preincubation of mononuclear cells with theophylline did not lead to a significant diminution of the number of E-RFC. The majority of patients demonstrated the activity of all the above-indicated suppressors upon the use of mitogens at several concentrations. Correlation of the NSA with the IgE magnitudes showed disagreement in all the cases with the exception of the test with short-lived suppressors (a variant of the test culture with Con A) where in one group of patients (11 examinees), a direct relationship was found, whereas in the other one (10 examinees), a reverse relationship. It is concluded that the test forms of NSA of lymphoid cells do not play an essential role in the maintenance of the total IgE level in pollinosis patients.
对36例花粉症患者进行了研究，这些患者对梯牧草花粉高度敏感，通过变应性病史数据、梯牧草过敏原皮肤试验和激发试验数据以及变应原特异性IgE抗体的存在得以证实。研究了总IgE水平和一些非特异性抑制活性（NSA）指标（茶碱敏感细胞数量以及伴刀豆球蛋白A诱导的自发和短期抑制细胞的活性）。IgE水平在23至2925KU/1之间。单核细胞与茶碱预孵育并未导致E-RFC数量显著减少。大多数患者在使用几种浓度的促有丝分裂原时表现出上述所有抑制细胞的活性。除了短期抑制细胞试验（伴刀豆球蛋白A试验培养变体）外，NSA与IgE水平在所有情况下均无相关性。在一组患者（11名受检者）中发现直接关系，而在另一组（10名受检者）中发现反向关系。得出的结论是，淋巴细胞NSA的检测形式在维持花粉症患者总IgE水平方面不起重要作用。
