Stanley T H
Can Anaesth Soc J. 1978 Jan;25(1):26-9. doi: 10.1007/BF03006779.
The cardiovascular effects of intravenous droperiodol 5 mg were measured in 20 patients during steady state enflurane-nitrous oxide-oxygen or enflurane-oxygen anaesthesia, droperiodol produced significant decreases in SVR and BP and increases in HR and Qt which were maximal after five minutes, somewhat less five minutes, somewhat less five minutes later, and back to control values 15 minutes after administration. SV was not significantly altered by droperiodol during enflurane-nitrous oxide-oxygen at any time after administration. During enflurane-oxygen anaesthesia droperidol reduced SVR and BP after five and ten minutes but did not significantly alter any other variable. All variables had returned to control levels 15 minutes after droperiodol during enfluarne-oxygen anaesthesia. These data demonstrate that droperidol produces a significant though transiet reduction of BP and SVR during enfluane anaesthesia which is associated with no change or an increase in Qt. Our findings suggest that droperidol causes minimal or no myocardial depression when used during potent inhalation anaesthesia and may have a place as an amnesic supplement and/or "afterload" reducer during light enflurance anaesthesia.
在20例处于恩氟烷 - 氧化亚氮 - 氧气或恩氟烷 - 氧气麻醉稳态的患者中，测量了静脉注射5毫克氟哌利多的心血管效应。氟哌利多使体循环血管阻力（SVR）和血压显著降低，心率（HR）和心输出量（Qt）增加，给药五分钟后达到最大值，五分钟后有所降低，再五分钟后降低幅度更大，给药15分钟后恢复至对照值。在恩氟烷 - 氧化亚氮 - 氧气麻醉期间，给药后任何时间氟哌利多均未显著改变每搏输出量（SV）。在恩氟烷 - 氧气麻醉期间，氟哌利多在五分钟和十分钟后降低了SVR和血压，但未显著改变任何其他变量。在恩氟烷 - 氧气麻醉期间，氟哌利多给药15分钟后所有变量均恢复至对照水平。这些数据表明，在恩氟烷麻醉期间，氟哌利多会导致血压和SVR显著但短暂地降低，这与Qt不变或增加有关。我们的研究结果表明，在强效吸入麻醉期间使用氟哌利多时，其对心肌的抑制作用极小或无抑制作用，并且在轻度恩氟烷麻醉期间，它可能作为遗忘辅助药物和/或“后负荷”降低剂发挥作用。
