Roti J L, Bohling V, Dethlefsen L A
Cell Tissue Kinet. 1978 Jan;11(1):1-21. doi: 10.1111/j.1365-2184.1978.tb00871.x.
Three models of tumor cell loss are described. The effects of cell loss on other cellular kinetic parameters are evaluated, and experiments which may distinguish among the models are discussed. Each model is based on a different cell-loss mechanism, and equations for the cell-cycle, cell-frequency distribution, the growth of both the proliferating and non-proliferating cell population, the growth fraction (GF), and the relative rate of volumetric growth, (dV/dt)/V, are derived. The following types of data are simulated for each model: the pulse labelling index, the mitotic index, and the labeling index as a function of time after a single or a series of 3H-TdR injections. The relative volumetric growth rate has the same mathematical form for each model. The PLM curves predicted by each model for the tumor lines studied (S102F and Slow) are not appreciably different. The predicted initial labeling index and mitotic index may differ significantly among the models depending upon the tumor line. The most striking difference among the models lies in the predictions regarding the labeling index as a function of time after a single or after a series of 3H-TdR injections. These types of labeling experiments should be valuable for distinguishing the different cell-loss mechanisms in solid tumors.
描述了三种肿瘤细胞丢失模型。评估了细胞丢失对其他细胞动力学参数的影响，并讨论了可区分这些模型的实验。每个模型都基于不同的细胞丢失机制，并推导了细胞周期、细胞频率分布、增殖细胞群和非增殖细胞群的生长、生长分数（GF）以及体积生长相对速率（dV/dt）/V的方程。针对每个模型模拟了以下类型的数据：脉冲标记指数、有丝分裂指数以及单次或一系列3H-TdR注射后标记指数随时间的变化。每个模型的体积生长相对速率具有相同的数学形式。每个模型针对所研究的肿瘤系（S102F和Slow）预测的PLM曲线没有明显差异。根据肿瘤系的不同，各模型预测的初始标记指数和有丝分裂指数可能存在显著差异。各模型之间最显著的差异在于单次或一系列3H-TdR注射后标记指数随时间变化的预测。这些类型的标记实验对于区分实体瘤中不同的细胞丢失机制应该是有价值的。
