Flint M H, Craig A S, Reilly H C, Gillard G C, Parry D A
Connect Tissue Res. 1984;13(1):69-81. doi: 10.3109/03008208409152144.
Samples of anatomically and functionally distinct regions of the skin of a variety of altricial and precocial animals were taken at various stages of development from birth to beyond maturity. The glycosaminoglycan (GAG) content and composition of the tissues were determined by chemical analysis and the collagen fibril diameters measured by transmission electron microscopy. The fibril diameters of the skins of two fish and a bird were also assessed for comparison. Analysis and comparison of the data collected show that there was a significant correlation between collagen fibril diameter distribution, GAG type and amount, and functional load-bearing of the various skins, and that the variations in the biochemical and physical composition of the tissues at different stages of development could be related to both their post-conceptual maturity and their prospective functional loading.
在从出生到成熟后的不同发育阶段，采集了各种晚成雏和早成雏动物皮肤中解剖学和功能上不同区域的样本。通过化学分析确定组织中的糖胺聚糖（GAG）含量和组成，并通过透射电子显微镜测量胶原纤维直径。还评估了两种鱼类和一种鸟类皮肤的纤维直径以作比较。对所收集数据的分析和比较表明，各种皮肤的胶原纤维直径分布、GAG类型和数量与功能承重之间存在显著相关性，并且组织在不同发育阶段的生化和物理组成变化可能与其出生后的成熟度和预期的功能负荷有关。
