[Production of anti-idiotypic monoclonal antibodies that recognize the receptor for murine gamma interferon].

In this work we consider the possibility to produce a monoclonal antibody against murine interferon gamma receptor using an approach based on the anti-idiotypic network theory of Jerne. We have found a rat monoclonal antibody (C-28) directed against the combining site of AN-18, a rat monoclonal antibody neutralizing murine interferon gamma activity, that is able to bind interferon receptor.