酒精综合征：乙醛的重组内效应。
The alcohol syndromes: the intrarecombigenic effect of acetaldehyde.
作者信息
Véghelyi P V, Osztovics M
出版信息
Experientia. 1978 Feb 15;34(2):195-6. doi: 10.1007/BF01944673.
PMID:624349
Abstract
Sister chromatid exchange was studied in lymphocyte and fibroblast cultures. Alcohol caused no disturbance under normal conditions but an acetaldehyde level above 40 muM inhibited cell multiplication and elevated SCE considerably. A high acetaldehyde level is thought to elicit the fetal alcohol syndrome, a view supported by clinical and experimental observations.
摘要
在淋巴细胞和成纤维细胞培养物中研究了姐妹染色单体交换。在正常条件下酒精不会造成干扰，但乙醛水平高于40微摩尔时会抑制细胞增殖并显著提高姐妹染色单体交换。高乙醛水平被认为会引发胎儿酒精综合征，这一观点得到了临床和实验观察的支持。
Zotero 插件