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酒精综合征:乙醛的重组内效应。

The alcohol syndromes: the intrarecombigenic effect of acetaldehyde.

作者信息

Véghelyi P V, Osztovics M

出版信息

Experientia. 1978 Feb 15;34(2):195-6. doi: 10.1007/BF01944673.

DOI:10.1007/BF01944673
PMID:624349
Abstract

Sister chromatid exchange was studied in lymphocyte and fibroblast cultures. Alcohol caused no disturbance under normal conditions but an acetaldehyde level above 40 muM inhibited cell multiplication and elevated SCE considerably. A high acetaldehyde level is thought to elicit the fetal alcohol syndrome, a view supported by clinical and experimental observations.

摘要

在淋巴细胞和成纤维细胞培养物中研究了姐妹染色单体交换。在正常条件下酒精不会造成干扰,但乙醛水平高于40微摩尔时会抑制细胞增殖并显著提高姐妹染色单体交换。高乙醛水平被认为会引发胎儿酒精综合征,这一观点得到了临床和实验观察的支持。

相似文献

1
The alcohol syndromes: the intrarecombigenic effect of acetaldehyde.酒精综合征:乙醛的重组内效应。
Experientia. 1978 Feb 15;34(2):195-6. doi: 10.1007/BF01944673.
2
Increased frequency of acetaldehyde-induced sister-chromatid exchanges in human lymphocytes treated with an aldehyde dehydrogenase inhibitor.用醛脱氢酶抑制剂处理的人淋巴细胞中,乙醛诱导的姐妹染色单体交换频率增加。
Mutat Res. 1991 Nov;264(3):103-7. doi: 10.1016/0165-7992(91)90124-m.
3
Influence of chronic ethanol uptake and acute acetaldehyde treatment on the chromosomes of bone-marrow cells and peripheral lymphocytes of Chinese hamsters.
Mutat Res. 1981 Apr;88(4):389-95. doi: 10.1016/0165-1218(81)90030-6.
4
[Effect of the combined action of cadmium and ethyl alcohol or cadmium and acetaldehyde on the genesis of sister chromatid exchange in lymphocytes of human blood in vitro].[镉与乙醇或镉与乙醛联合作用对体外人血淋巴细胞姐妹染色单体交换发生的影响]
Rocz Panstw Zakl Hig. 1989;40(1):53-7.
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The frequency of sister chromatid exchanges in human lymphocytes treated with ethanol and acetaldehyde.乙醇和乙醛处理的人淋巴细胞中姐妹染色单体交换的频率。
Hereditas. 1982;97(2):301-3. doi: 10.1111/j.1601-5223.1982.tb00774.x.
6
Effects of ethanol, acetaldehyde and disulfiram on the metabolism of biogenic aldehydes in isolated human blood cells and platelets.乙醇、乙醛和双硫仑对分离的人体血细胞和血小板中生物源性醛代谢的影响。
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Sister chromatid exchanges in lymphocytes of normal and alcoholic subjects.正常人和酗酒者淋巴细胞中的姐妹染色单体交换
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8
Recombinant human diamine oxidase activity is not inhibited by ethanol, acetaldehyde, disulfiram, diethyldithiocarbamate or cyanamide.重组人二胺氧化酶活性不受乙醇、乙醛、双硫仑、二乙基二硫代氨基甲酸盐或氨基氰的抑制。
Alcohol. 2016 Aug;54:51-9. doi: 10.1016/j.alcohol.2016.06.001. Epub 2016 Jun 29.
9
Synergistic interaction between hydroquinone and acetaldehyde in the induction of sister chromatid exchange in human lymphocytes in vitro.对苯二酚与乙醛在体外诱导人淋巴细胞姐妹染色单体交换中的协同相互作用。
Cancer Res. 1985 Oct;45(10):4853-7.
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Effects of alcohol, antabuse and acetaldehyde upon the EEG of rabbits.酒精、安塔布司及乙醛对家兔脑电图的影响。
Jpn J Pharmacol. 1956 Mar;5(2):139-50. doi: 10.1254/jjp.5.139.

引用本文的文献

1
Sister chromatid exchanges in lymphocytes of normal and alcoholic subjects.正常人和酗酒者淋巴细胞中的姐妹染色单体交换
Experientia. 1992 May 15;48(5):508-12. doi: 10.1007/BF01928176.
2
Maternal alcohol consumption and birth weight.母亲饮酒与出生体重。
Br Med J. 1978 Nov 11;2(6148):1365-6. doi: 10.1136/bmj.2.6148.1365-b.

本文引用的文献

1
[Effects of alcoholized beverages on reproduction in rats].[酒精饮料对大鼠生殖的影响]
C R Hebd Seances Acad Sci. 1958 Feb 24;246(8):1275-7.
2
Effect of ethanol on the growth and on the liver and brain mitochondrial functions of the offspring of rats.
Acta Pharmacol Toxicol (Copenh). 1967;25(2):225-32. doi: 10.1111/j.1600-0773.1967.tb01427.x.
3
Enzyme activities and ethanol preference in mice.
Biochem Genet. 1968 Nov;2(3):205-12. doi: 10.1007/BF01474759.
4
Metabolism of ethanol and acetaldehyde in intact rats during pregnancy.
孕期完整大鼠体内乙醇和乙醛的代谢
Biochem Pharmacol. 1974 Apr 1;23(7):1157-62. doi: 10.1016/0006-2952(74)90289-5.
5
New Giemsa method for the differential staining of sister chromatids.用于姐妹染色单体鉴别染色的新吉姆萨方法。
Nature. 1974 Sep 13;251(5471):156-8. doi: 10.1038/251156a0.
6
[On the embryo-fetal alcohol syndrome (author's transl)].论胚胎-胎儿酒精综合征(作者译)
Eur J Pediatr. 1976 Feb 4;121(3):155-77. doi: 10.1007/BF00445480.
7
High blood acetaldehyde levels after ethanol administration. Difference between alcoholic and nonalcoholic subjects.乙醇摄入后血液中乙醛水平升高。酒精性和非酒精性受试者之间的差异。
N Engl J Med. 1975 Feb 20;292(8):386-9. doi: 10.1056/NEJM197502202920802.
8
The disulfiram--ethanol reaction: a review.
J Stud Alcohol. 1977 Jan;38(1):96-113. doi: 10.15288/jsa.1977.38.96.
9
Liver aldehyde and alcohol dehydrogenase activities in rat strains genetically selected for their ethanol preference.
Biochem Pharmacol. 1975 Oct 1;24(19):1807-11. doi: 10.1016/0006-2952(75)90461-x.