人结肠腺苷酸环化酶。血管活性肠肽和各种前列腺素通过不同受体位点对酶活性的刺激作用。

Human colonic adenylate cyclase. Stimulation of enzyme activity by vasoactive intestinal peptide and various prostaglandins via distinct receptor sites.

作者信息

Simon B, Kather H

出版信息

Digestion. 1980;20(1):62-7. doi: 10.1159/000198415.

DOI:10.1159/000198415

Abstract

The effects of meclofenamic acid on basal and hormone-stimulated adenylate cyclase in human colonic mucosa were tested. It is shown that meclofenamic acid is a relatively specific inhibitor of the stimulatory action of prostaglandins on the level of mucosal adenylate cyclase. This compound did not inhibit significantly the effects of vasoactive intestinal peptide (VIP) on the human enzyme system. VIP18-28 did not act as a partial agonist and did not inhibit the response to the intact VIP. Our studies suggest the existence of distinct receptor sites for both secretagogues (VIP and prostaglandins) in human colonic mucosa.

摘要

测试了甲氯芬那酸对人结肠黏膜中基础和激素刺激的腺苷酸环化酶的作用。结果表明，甲氯芬那酸是前列腺素对黏膜腺苷酸环化酶水平刺激作用的相对特异性抑制剂。该化合物对血管活性肠肽（VIP）对人酶系统的作用没有显著抑制作用。VIP18 - 28既不充当部分激动剂，也不抑制对完整VIP的反应。我们的研究表明，在人结肠黏膜中，两种促分泌素（VIP和前列腺素）存在不同的受体位点。