Dundarov S, Andonov P, Bakalov B
Arch Virol. 1980;63(2):115-21. doi: 10.1007/BF01320768.
Herpes simplex virus strains (HSV) were isolated from various herpetic diseases. These HSV-strains isolated in Bulgaria (687) and in other countries (13) were studied by the neutralization test using standard type specific rabbit antisera and human gamma globulin. The serotype distribution of all strains showed: HSV-1 = 323 strains, HSV-2 = 372 strains, 5 strains behaved antigenically intermediate. A close correlation between the serotype of the strains and the localization of the lesions was established. All but four strains (1.24 per cent) isolated from the head belong to HSV-1, and only six HSV-strains (1.9 per cent) from lesions with other localizations were not HSV-2. Within six months to 8 years 2 to 4 herpes strains were isolated repeatedly from 30 patients. In 23 of these cases they were identical and in the other they showed different biological (3) or antigenical (4) properties. The results suggest, that under natural conditions some HSV-intermediate strains may exist.
单纯疱疹病毒株（HSV）从各种疱疹性疾病中分离得到。使用标准型特异性兔抗血清和人丙种球蛋白，通过中和试验对在保加利亚分离的这些HSV株（687株）以及在其他国家分离的（13株）进行了研究。所有毒株的血清型分布显示：HSV - 1 = 323株，HSV - 2 = 372株，5株表现为抗原性中间型。毒株血清型与病变部位之间建立了密切关联。从头部分离的毒株中，除4株（1.24%）外均属于HSV - 1，而从其他部位病变分离的HSV毒株中，仅有6株（1.9%）不是HSV - 2。在6个月至8年的时间里，从30名患者中反复分离出2至4株疱疹毒株。在其中23例中，这些毒株是相同的，在其他病例中，它们表现出不同的生物学特性（3例）或抗原特性（4例）。结果表明，在自然条件下可能存在一些HSV中间型毒株。
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