锂对人体肾上腺素刺激引起的血浆环磷酸鸟苷升高的部分抑制作用。
Partial inhibition by lithium of the epinephrine-stimulated rise in plasma cyclic GMP in humans.
作者信息
Belmaker R H, Kon M, Ebstein R P, Dasberg H
出版信息
Biol Psychiatry. 1980 Feb;15(1):3-8.
PMID:6244010
Abstract
Lithium-treated and drug-free individuals were each given 0.5 mg epinephrine subcutaneously and blood samples withdrawn for measurement of plasma cyclic AMP and cyclic GMP. The rise in plasma cyclic GMP in response to epinephrine was found to be partially inhibited by lithium treatment, and previous reports of lithium inhibition of the plasma cyclic AMP rise were replicated. Effects of lithium on cyclic AMP and cyclic GMP may relate to lithium's biphasic efficacy in depression and mania.
摘要
对接受锂治疗的个体和未服用药物的个体分别皮下注射0.5毫克肾上腺素，并采集血样以测量血浆环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）。结果发现，锂治疗可部分抑制肾上腺素引起的血浆cGMP升高，并且重复了先前关于锂抑制血浆cAMP升高的报道。锂对cAMP和cGMP的影响可能与其在抑郁症和躁狂症中的双相疗效有关。
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