Willig R P, Lagenstein I
Monatsschr Kinderheilkd (1902). 1980 Feb;128(2):100-3.
Epilepsy in early childhood has been treated successfully with ACTH. However, side effects were significant due to the stimulation of the adrenal cortex by high doses of ACTH over a long time. It has been suggested, that ACTH does not influence the seizures via the adrenal cortex. Therefore we administered an ACTH fragment (ACTH 4-10) which does not influence the adrenal cortex. Seven children aged between 8 months and 13 1/2 years were treated at least for 3 weeks with doses from 15 mg twice daily to 12 x 30 mg/day. Adrenal stimulation did not occur as proven by normal circadian plasma cortisol levels. However, the EEG regularly repeated, did not show improvements. The frequency of seizure was not reduced. It is concluded that this ACTH fragment (ACTH 4-10) does neither influence the adrenal cortex nor the EEG nor the frequency of seizures in early childhood epilepsy.
促肾上腺皮质激素（ACTH）已成功用于治疗幼儿癫痫。然而，由于长期大剂量使用ACTH刺激肾上腺皮质，副作用较为显著。有人提出，ACTH并非通过肾上腺皮质影响癫痫发作。因此，我们给予一种不影响肾上腺皮质的ACTH片段（ACTH 4-10）。对7名年龄在8个月至13岁半的儿童进行治疗，剂量为每日两次15毫克至每日12×30毫克，至少治疗3周。正常的昼夜血浆皮质醇水平证明未发生肾上腺刺激。然而，定期重复的脑电图未显示改善。癫痫发作频率未降低。得出的结论是，这种ACTH片段（ACTH 4-10）对幼儿癫痫的肾上腺皮质、脑电图及癫痫发作频率均无影响。
