实验性胶质瘤：内皮成分的放射自显影研究

Experimental gliomas: an autoradiographic study of the endothelial component.

作者信息

Groothuis D R, Fischer J M, Vick N A, Bigner D D

出版信息

Neurology. 1980 Mar;30(3):297-301. doi: 10.1212/wnl.30.3.297.

DOI:10.1212/wnl.30.3.297

Abstract

Autochthonous gliomas were induced in rats by intracerebral inoculation of avian of avian sarcoma virus and studied by 3H-thymidine autoradiography. Parenchymal glial tumor cells had a 3H-labeling index (LI) of 3.0 to 13.6%. Endothelial cells in tumor blood vessels had an LI of 2.6 to 34.3%, independent of and in most instances higher than the LI of the glial tumor. Endothelial cells of normal blood vessels had an average LI of 0.3%. This study documents the high proliferative rate of the endothelial cells in anaplastic experimental gliomas, and emphasizes the necessity for seeking direct, incontrovertible evidence to determine whether or not the rapidly proliferating endothelial cells are malignant.

摘要

通过脑内接种禽肉瘤病毒在大鼠中诱发原发性胶质瘤，并采用3H-胸腺嘧啶核苷放射自显影术进行研究。实质神经胶质肿瘤细胞的3H标记指数（LI）为3.0%至13.6%。肿瘤血管中的内皮细胞LI为2.6%至34.3%，与神经胶质肿瘤的LI无关，且在大多数情况下高于神经胶质肿瘤的LI。正常血管的内皮细胞平均LI为0.3%。本研究记录了间变性实验性胶质瘤中内皮细胞的高增殖率，并强调有必要寻找直接、确凿的证据来确定快速增殖的内皮细胞是否为恶性。