[4-色氨酸]脑啡肽类似物的合成、体外阿片样活性及分子内酪氨酸-色氨酸距离。对溶液中脑啡肽构象模型的重新评估。 - Suppr | 超能文献

Synthesis, in vitro opiate activity, and intramolecular tyrosine--tryptophan distances of [4-tryptophan]enkephalin analogues. A reassessment of conformational models of enkephalin in solution.

作者信息

Schiller P W, St-Hilaire J

出版信息

J Med Chem. 1980 Mar;23(3):290-4. doi: 10.1021/jm00177a016.

DOI:10.1021/jm00177a016

Abstract

摘要

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Synthesis, in vitro opiate activity, and intramolecular tyrosine--tryptophan distances of [4-tryptophan]enkephalin analogues. A reassessment of conformational models of enkephalin in solution.[4-色氨酸]脑啡肽类似物的合成、体外阿片样活性及分子内酪氨酸-色氨酸距离。对溶液中脑啡肽构象模型的重新评估。

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Synthesis, opiate receptor affinity, and conformational parameters of [4-tryptophan]enkephalin analogues.

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引用本文的文献

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Preparation and evaluation at the delta opioid receptor of a series of linear leu-enkephalin analogues obtained by systematic replacement of the amides.通过系统取代酰胺，获得一系列线性亮氨酸脑啡肽类似物，并对其在 delta 阿片受体上的作用进行了制备和评价。

ACS Chem Neurosci. 2013 Aug 21;4(8):1204-16. doi: 10.1021/cn4000583. Epub 2013 May 20.

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A cyclic enkephalin analog with high in vitro opiate activity.一种具有高体外阿片样活性的环脑啡肽类似物。

Proc Natl Acad Sci U S A. 1980 Dec;77(12):7162-6. doi: 10.1073/pnas.77.12.7162.