促肿瘤佛波酯在体外刺激造血集落形成。
Tumor-promoting phorbol esters stimulate hematopoietic colony formation in vitro.
作者信息
Stuart R K, Hamilton J A
出版信息
Science. 1980 Apr 25;208(4442):402-4. doi: 10.1126/science.6245446.
PMID:6245446
Abstract
Tumor-promoting phorbol esters stimulated mouse bone marrow cells to form myeloid colonies in agar cultures without added colony-stimulating factors. The colony-stimulating ability of various phorbol esters correlated well with their ability to promote skin tumors in vivo. These results suggest that phorbol esters mimic the action of specific colony-stimulating factors that regulate growth.
摘要
促肿瘤佛波酯可刺激小鼠骨髓细胞，使其在无添加集落刺激因子的琼脂培养物中形成髓系集落。各种佛波酯的集落刺激能力与其在体内促进皮肤肿瘤的能力密切相关。这些结果表明，佛波酯模拟了调节生长的特定集落刺激因子的作用。
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