Zankl H, Zang K D
Hum Genet. 1978 Jan 19;40(2):149-55. doi: 10.1007/BF00272295.
The association pattern was studied in 2715 mitoses of 90 meningiomas with different numbers of acrocentric chromosomes. In cells with monosomy 22, a significant increase of mitoses with associations was observed in comparison to cells with a normal karyotype. The number of associating acrocentric chromosomes was highly significantly increased. This surplus was not only caused by a highly significant increase of associating G chromosomes but also of D chromosomes. The loss of further acrocentric chromosomes had no significant influence on the number of mitoses with associations or the number of associating chromosomes. Based on the well-known correlations between the nucleolus organization and the association pattern, the results seem to indicate a compensation mechanism among the nucleoles organizing regions (NOR's) which keeps the supply of nucleolar material constant and simultaneously causes a higher association tendency between the remaining acrocentric chromosomes. The increase of associations in the 22 monosomic cells was interpreted as a overcompensation after the loss of only one NOR.
对90例具有不同数量近端着丝粒染色体的脑膜瘤的2715个有丝分裂进行了关联模式研究。与核型正常的细胞相比，在22号染色体单体细胞中，观察到有丝分裂中出现关联的情况显著增加。发生关联的近端着丝粒染色体数量极显著增加。这种过剩不仅是由于发生关联的G组染色体极显著增加，D组染色体也是如此。其他近端着丝粒染色体的缺失对出现关联的有丝分裂数量或发生关联的染色体数量没有显著影响。基于核仁组织与关联模式之间的已知相关性，结果似乎表明核仁组织区（NOR）之间存在一种补偿机制，该机制使核仁物质的供应保持恒定，同时导致其余近端着丝粒染色体之间具有更高的关联倾向。22号染色体单体细胞中关联的增加被解释为仅一个NOR缺失后的过度补偿。
