出生后激素引发的大鼠肝脏线粒体成熟
Hormone-initiated maturation of rat liver mitochondria after birth.
作者信息
Sutton R, Pollak J K
出版信息
Biochem J. 1980 Jan 15;186(1):361-7. doi: 10.1042/bj1860361.
Abstract
- The injection of adrenaline, glucagon or cyclic AMP into foetal rats in utero initiates the maturation of energy transduction in rat liver mitochondria before birth. 2. The injection of the beta-blocker, propranolol, prevents this maturation process. 3. The maturation of mitochondrial energy transduction is measured in terms of the increase in the respiratory control index and mitochondrial adenine nucleotide concentration. 4. It is postulated that the actions of the hormones, acting through cyclic AMP, affect glycogenolysis and glycolysis to give rise to transient localized high concentrations of ATP. 5. It is the ATP that acts as the molecular trigger, effecting mitochondrial maturation.
摘要
- 向子宫内的胎鼠注射肾上腺素、胰高血糖素或环磷酸腺苷可在出生前启动大鼠肝脏线粒体能量转导的成熟过程。2. 注射β受体阻滞剂普萘洛尔可阻止这一成熟过程。3. 线粒体能量转导的成熟通过呼吸控制指数和线粒体腺嘌呤核苷酸浓度的增加来衡量。4. 据推测，激素通过环磷酸腺苷起作用，影响糖原分解和糖酵解，从而产生短暂的局部高浓度三磷酸腺苷（ATP）。5. 正是ATP作为分子触发因素，促使线粒体成熟。
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