Nolan J C, Ridge S C, Oronsky A L, Kerwar S S
Atherosclerosis. 1980 Jan;35(1):93-102. doi: 10.1016/0021-9150(80)90031-3.
Bovine medial explants in culture synthesize a potent inhibitor of mammalian collagenase but not of bacterial collagenase. This inhibitor has been partially purified and has an apparent molecular weight of 45,000. It is a glycoprotein and is stable to heat, trypsin, acid and mercurials. Inhibitory activity is destroyed on reductive alkylation. The inhibitor interacts with collagenase and this interaction leads to the loss of enzymatic activity. This inhibitor may play a physiological role in the control of collagen degradation in blood vessels.
培养中的牛内侧外植体可合成一种有效的哺乳动物胶原酶抑制剂，但不能合成细菌胶原酶抑制剂。这种抑制剂已被部分纯化，其表观分子量为45,000。它是一种糖蛋白，对热、胰蛋白酶、酸和汞稳定。还原烷基化会破坏其抑制活性。该抑制剂与胶原酶相互作用，这种相互作用会导致酶活性丧失。这种抑制剂可能在控制血管中胶原降解方面发挥生理作用。
