Atlas D, Volsky D J, Levitzki A
Biochim Biophys Acta. 1980 Mar 27;597(1):64-9. doi: 10.1016/0005-2736(80)90150-9.
Cationized ferritin was found to inhibit the lateral mobility of intramembrane proteins in turkey erythrocyte membranes and the activation of adenylate cyclase by the (--)-epinephrine-bound beta-adrenergic receptor. It was observed that cationized ferritin has only a small direct effect on the beta-receptor and on the adenylate cyclase moiety. It is concluded that the cationized ferritin-induced inhibition of the hormone-dependent cyclase activity results from the inhibition of the lateral mobility of the receptor and therefore a decrease in the bimolecular rate of interaction between the receptor and the enzyme.
已发现阳离子铁蛋白可抑制火鸡红细胞膜中膜内蛋白质的侧向移动以及由（-）-肾上腺素结合的β-肾上腺素能受体激活腺苷酸环化酶。据观察，阳离子铁蛋白对β受体和腺苷酸环化酶部分仅有微小的直接作用。得出的结论是，阳离子铁蛋白诱导的激素依赖性环化酶活性抑制是由于受体侧向移动受到抑制，因此受体与酶之间的双分子相互作用速率降低。
