Kokubu T, Ueda E, Ono M, Kawabe T, Hayashi Y, Kan T
Eur J Pharmacol. 1980 Apr 4;62(4):269-75. doi: 10.1016/0014-2999(80)90094-1.
High doses of captopril (SQ 14, 225) (120-160 mg/kg/day) were administered orally to normal rats, and the effects on the renin-angiotensin-aldosterone system were observed. Plasma angiotensin converting enzyme (ACE) activity was elevated significantly on the 3rd, 7th and 30th days of captopril administration. ACE activity in the lung and the kidney was significantly decreased on the 1st day then gradually increased, becoming significantly higher than that of controls by the 30th day. Plasma renin activity (PRA) was significantly elevated on the 1st day and remained at a high level until the 30th day. Renal renin content was found to be significantly lower on the 1st and 3rd days. Plasma aldosterone concentration was not affected by captopril treatment, whereas serum potassium concentration was found to be significantly lower on the 1st, 3rd and 30th days. It is suggested that besides its inhibitory action on ACE, captopril has a direct or indirect stimulating action on ACE production as well as on renin release.
给正常大鼠口服大剂量卡托普利（SQ 14,225）（120 - 160毫克/千克/天），并观察其对肾素 - 血管紧张素 - 醛固酮系统的影响。在给予卡托普利的第3天、第7天和第30天，血浆血管紧张素转换酶（ACE）活性显著升高。肺和肾脏中的ACE活性在第1天显著降低，然后逐渐升高，到第30天时显著高于对照组。血浆肾素活性（PRA）在第1天显著升高，并一直保持在高水平直至第30天。发现肾脏肾素含量在第1天和第3天显著降低。血浆醛固酮浓度不受卡托普利治疗的影响，而血清钾浓度在第1天、第3天和第30天显著降低。提示卡托普利除了对ACE有抑制作用外，对ACE的产生以及肾素释放还有直接或间接的刺激作用。
