拓扑异构酶对动质体DNA的解连环作用。
Decatenation of kinetoplast DNA by topoisomerases.
作者信息
Marini J C, Miller K G, Englund P T
出版信息
J Biol Chem. 1980 Jun 10;255(11):4976-9.
PMID:6246090
Abstract
Kinetoplast DNA is the mitochondrial DNA of trypanosomatids such as Crithidia fasciculata. This DNA is in the form of networks containing thousands of DNA circles which are apparently catenated (interlocked). Some topoisomerases, such as T4 phage topoisomerase and DNA gyrase, catalyze a decatenation of the networks to form individual covalently closed circles.
摘要
动质体DNA是锥虫（如纤细无脊椎锥虫）的线粒体DNA。这种DNA呈网络状，包含数千个明显连环（互锁）的DNA环。一些拓扑异构酶，如T4噬菌体拓扑异构酶和DNA促旋酶，催化网络的解连环，形成单个共价闭合环。
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