Wong-Riley M T, Welt C
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2333-7. doi: 10.1073/pnas.77.4.2333.
The posteromedial barrel subfield of the somatosensory cortex of mice was examined histochemically for cytochrome oxidase activity (cytochrome c oxidase; ferrocytochrome c:oxygen oxidoreductase, EC 1.9.3.1). In normal mice a high enzymatic activity was found within the barrel hollows, rather than in the sides and septa. Electron microscopic examination indicated that within the hollows reactive mitochondria reside in many dendrites, in some axonal terminals, and in a few neuronal perikarya. After neonatal cauterization of selected row(s) of vibrissae, the corresponding row(s) of barrels appeared as narrowed fused band(s) and their cytochrome oxidase activity was much reduced. Removal of vibrissae in the adult, by either cauterization or repeated plucking, did not cause size changes of cortical barrels. However, there was a significant decrease in the oxidative enzymatic activity within these barrels. Thus, the deprivation of sensory input through damage to, or removal of, the peripheral sensory organ induces an enzymatic response in neurons that are at least two to three synapses away from the periphery.
对小鼠体感皮层的后内侧桶状亚区进行了细胞色素氧化酶活性（细胞色素c氧化酶；亚铁细胞色素c：氧氧化还原酶，EC 1.9.3.1）的组织化学检查。在正常小鼠中，发现桶状凹陷内的酶活性较高，而不是在桶壁和桶间隔中。电子显微镜检查表明，在凹陷内，有活性的线粒体存在于许多树突、一些轴突终末和少数神经元胞体中。在新生小鼠中对选定排的触须进行烧灼后，相应排的桶状结构呈现为变窄的融合带，其细胞色素氧化酶活性大大降低。在成年小鼠中，通过烧灼或反复拔除去除触须，并未导致皮层桶状结构大小发生变化。然而，这些桶状结构内的氧化酶活性显著降低。因此，通过损伤或去除外周感觉器官而剥夺感觉输入，会在距离外周至少两到三个突触的神经元中诱导酶反应。
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