Cherek D R, Thompson T, Kelly T
Pharmacol Biochem Behav. 1980 Feb;12(2):305-9. doi: 10.1016/0091-3057(80)90374-3.
The effects of 0.5 mg/kg and 1.0 mg/kg of delta 9-tetrahydrocannabinol (delta 9-THC) on key-pecking maintained by a response-initiated fixed interval (FI) schedule of food presentation and schedule-induced aggression in the pigeon were studied. Initially, following the administration of delta 9-THC both the rate of key-pecking and attack responding were markedly reduced. Over sessions, tolerance developed to the suppressant effect on key-pecking, with the rate returning to the predrug level. The suppressing effect of delta 9-THC on the rate of attack remained at or near zero throughout the series of delta 9-THC injections.
研究了0.5毫克/千克和1.0毫克/千克的δ9-四氢大麻酚(δ9-THC)对鸽子通过反应启动的固定间隔(FI)食物呈现时间表维持的啄键行为以及时间表诱导的攻击行为的影响。最初,给予δ9-THC后,啄键率和攻击反应率均显著降低。随着实验阶段的进行,对啄键抑制作用产生了耐受性,啄键率恢复到用药前水平。在整个δ9-THC注射系列中,δ9-THC对攻击率的抑制作用保持在或接近零。