Squires R F, Klepner C A, Benson D I
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Certain benzodiazepine receptors may be associated in different ways with GABA receptors and/or ion recognition sites, to yield multiple receptor complexes. The benzodiazepine recognition site may be the same in all of the complexes. The different elements of the complexes almost certainly interact allosterically (Fig. 5). Different benzodiazepine receptor complexes may mediate different pharmacological effects of these drugs.
某些苯二氮䓬受体可能以不同方式与γ-氨基丁酸(GABA)受体和/或离子识别位点相关联,从而产生多种受体复合物。苯二氮䓬识别位点在所有复合物中可能是相同的。复合物的不同成分几乎肯定会通过变构作用相互作用(图5)。不同的苯二氮䓬受体复合物可能介导这些药物的不同药理作用。