Steere A C, Brinckerhoff C E, Miller D J, Drinker H, Harris E D, Malawista S E
Arthritis Rheum. 1980 May;23(5):591-9. doi: 10.1002/art.1780230511.
A patient with chronic Lyme arthritis and roentgenographic evidence of bony erosion underwent a synovectomy; proliferative synovium (pannus), containing aggregates of small lymphocytes, was found adherent to eroded cartilage and bone. During 8 days in tissue culture, the synovial cells produced large amounts of collagenase and prostaglandin E2, but only low levels of both neutral and acid proteinases. Sixty-seven percent of the lymphocytes from the synovium were T cells; 19% were B cells. Attempts to identify agent/antigen in the synovial cells were unsuccessful. Thus, the synovium of this patient, whose disease appears to be tick-transmitted, resembles that of rheumatoid arthritis. This finding further supports the hypothesis that many possible agents, including infectious ones, trigger a common pathway in synovium, which leads to joint destruction.
一名患有慢性莱姆关节炎且有骨侵蚀影像学证据的患者接受了滑膜切除术；发现增殖性滑膜（血管翳）附着于侵蚀的软骨和骨，其中含有小淋巴细胞聚集物。在组织培养的8天时间里，滑膜细胞产生了大量胶原酶和前列腺素E2，但中性和酸性蛋白酶的水平都很低。滑膜中67%的淋巴细胞是T细胞；19%是B细胞。在滑膜细胞中鉴定病原体/抗原的尝试未成功。因此，该患者的滑膜（其疾病似乎是通过蜱传播的）与类风湿关节炎的滑膜相似。这一发现进一步支持了以下假设：许多可能的病原体，包括传染性病原体，在滑膜中触发了一条共同途径，从而导致关节破坏。
