吲哚美辛对环磷酸腺苷依赖性蛋白激酶的作用。

Effect of indomethacin on the cyclic AMP-dependent protein kinase.

作者信息

Catalán R E, Aragones M D, Martinez A M, Armijo M, Piña M

出版信息

Eur J Pharmacol. 1980 May 2;63(2-3):187-90. doi: 10.1016/0014-2999(80)90443-4.

Abstract

Indomethacin inhibited cyclic AMP-dependent protein kinase activity in small intestine in in vivo experiments. An inverse pattern of variation was exhibited by acetyl salicylic acid, eterylate and benorylate, acetyl-p-amino-phenol being inactive. Indomethacin, acetyl salicylic acid, eterylate and benorylate increased the protein kinase activity in liver, lung and heart after in vivo administration. The in vivo effect of indomethacin was confirmed by in vitro experiments with small intestine and heart protein kinases. These results support the concept that indomethacin can affect protein kinase activity in a tissue-specific way.

摘要

在体内实验中，吲哚美辛抑制小肠中依赖环磷酸腺苷的蛋白激酶活性。乙酰水杨酸、依托酯和贝诺酯呈现出相反的变化模式，对乙酰氨基酚无活性。在体内给药后，吲哚美辛、乙酰水杨酸、依托酯和贝诺酯可增加肝脏、肺和心脏中的蛋白激酶活性。用小肠和心脏蛋白激酶进行的体外实验证实了吲哚美辛的体内效应。这些结果支持了吲哚美辛可通过组织特异性方式影响蛋白激酶活性这一观点。