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吲哚美辛促进布氏锥虫的分化。

Indomethacin promotes differentiation of Trypanosoma brucei.

作者信息

Jack R M, Black S J, Reed S L, Davis C E

出版信息

Infect Immun. 1984 Jan;43(1):445-8. doi: 10.1128/iai.43.1.445-448.1984.

DOI:10.1128/iai.43.1.445-448.1984
PMID:6690416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC263462/
Abstract

The treatment of mice with indomethacin lowered Trypanosoma brucei parasitemia 1 to 2 log10 because it quickly promoted the differentiation of rapidly dividing long, slender trypanosomes into short, stumpy forms that do not divide in the mammal but do develop a functional mitochondrion and the ability to infect the tsetse. Since natural resistance correlates with the rate of differentiation, this observation may provide important information about factors that control the severity of trypanosomiasis.

摘要

用消炎痛治疗小鼠可使布氏锥虫血症降低1至2个对数级，因为它能迅速促使快速分裂的长形、细长型锥虫分化为短粗型，这种短粗型锥虫在哺乳动物体内不再分裂，但会发育出功能性线粒体并具备感染采采蝇的能力。由于天然抗性与分化速率相关，这一观察结果可能会为控制锥虫病严重程度的因素提供重要信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4051/263462/9ee883fa2617/iai00130-0469-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4051/263462/9ee883fa2617/iai00130-0469-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4051/263462/9ee883fa2617/iai00130-0469-a.jpg

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The trypanosome surface glycoprotein procyclin is expressed only on tsetse fly vector stages of the parasite.

本文引用的文献

1
A comparison between a syringe-passaged and a tsetse-fly-transmitted line of a strain of Trypanosoma rhodesiense.罗德西亚锥虫一个菌株的注射器传代株与采采蝇传播株之间的比较。
Ann Trop Med Parasitol. 1960 Apr;54:44-53. doi: 10.1080/00034983.1960.11685955.
2
Factors that may influence the infection rate of Glossina palpalis with Trypanosoma gambiense. II. The number and morphology of the trypano-somes present in the blood of the host at the time of the infected feed.可能影响冈比亚按蚊感染冈比亚锥虫感染率的因素。II. 受感染进食时宿主血液中存在的锥虫数量和形态。
Ann Trop Med Parasitol. 1960 Oct;54:341-50.
3
The polymorphism of Trypanosoma brucei and T. rhodesiense, its relation to relapses and remissions of infections in white rats, and the effect of cortisone.
锥虫表面糖蛋白前环素仅在寄生虫的采采蝇载体阶段表达。
Parasitol Res. 1989;76(2):171-3. doi: 10.1007/BF00930841.
布氏锥虫和罗德西亚锥虫的多态性、其与白鼠感染复发和缓解的关系以及可的松的作用。
Ann Trop Med Parasitol. 1957 Sep;51(3):301-12. doi: 10.1080/00034983.1957.11685819.
4
Humoral responses against Trypanosoma brucei variable surface antigen are induced by degenerating parasites.针对布氏锥虫可变表面抗原的体液免疫反应是由退化的寄生虫诱导产生的。
Parasite Immunol. 1982 Jul;4(4):245-57. doi: 10.1111/j.1365-3024.1982.tb00436.x.
5
Prostaglandin synthesis by lymphoid tissue of mice experiencing a graft-versus-host reaction: relationship to immunosuppression.经历移植物抗宿主反应的小鼠淋巴组织中前列腺素的合成：与免疫抑制的关系。
Cell Immunol. 1980 Mar 15;50(2):271-81. doi: 10.1016/0008-8749(80)90282-8.
6
Cyclic 3',5'-adenosine monophosphate levels during the developmental cycle of Trypanosoma brucei brucei in the rat.布氏布氏锥虫在大鼠体内发育周期中的环磷酸腺苷水平
Mol Biochem Parasitol. 1981 May;3(1):19-31. doi: 10.1016/0166-6851(81)90074-8.
7
Regulation of 3T3-L1 fibroblast differentiation by prostacyclin (prostaglandin I2).前列环素（前列腺素I2）对3T3-L1成纤维细胞分化的调节作用。
Biochim Biophys Acta. 1981 Feb 23;663(2):457-66. doi: 10.1016/0005-2760(81)90174-0.
8
Gametocytogenesis by malaria parasites in continuous culture.疟原虫在连续培养中的配子体形成
Nature. 1980 Jul 31;286(5772):490-2. doi: 10.1038/286490a0.
9
Effect of indomethacin on the cyclic AMP-dependent protein kinase.吲哚美辛对环磷酸腺苷依赖性蛋白激酶的作用。
Eur J Pharmacol. 1980 May 2;63(2-3):187-90. doi: 10.1016/0014-2999(80)90443-4.
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Host-parasite interactions which influence the virulence of Trypanosoma (Trypanozoon) brucei brucei organisms.影响布氏布氏锥虫（锥虫属）生物体毒力的宿主-寄生虫相互作用。
Acta Trop. 1983 Mar;40(1):11-8.