Russell D H
Pharmacology. 1980;20(3):117-29. doi: 10.1159/000137355.
Ornithine decarboxylase, the initial enzyme in the polyamine biosynthetic pathway, is induced in target tissues in response to a variety of trophic agents including polypeptide and amine trophic hormones, cyclic AMP analogs, drugs, and trophic steroid hormones. The induction of ornithine decarboxylase in these systems is regulated at a transcriptional level and is proportional to the extent of stimulation. Because of its rapid half-life (10-20 min), a general maximum of induction is detectable within 4-5 h of stimulation, and its induction pattern can serve as a rapid, specific index of increased RNA and protein synthesis. Implications for its usefulness to pharmacologists, endocrinologists, physiologists, and biochemists are summarized.
鸟氨酸脱羧酶是多胺生物合成途径中的起始酶，在包括多肽和胺类营养激素、环磷酸腺苷类似物、药物以及营养甾体激素在内的多种营养因子作用下，在靶组织中被诱导产生。在这些系统中，鸟氨酸脱羧酶的诱导作用在转录水平上受到调控，且与刺激程度成正比。由于其半衰期较短（10 - 20分钟），一般在刺激后4 - 5小时内可检测到最大诱导量，其诱导模式可作为RNA和蛋白质合成增加的快速、特异性指标。文中总结了其对药理学家、内分泌学家、生理学家和生物化学家的有用之处。
