神经生长因子可增加幼鼠颈上神经节中鸟氨酸脱羧酶的活性。
Nerve growth factor increases activity of ornithine decarboxylase in superior cervical ganglia of young rats.
作者信息
MacDonnell P C, Nagaiah K, Lakshmanan J, Guroff G
出版信息
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4681-4. doi: 10.1073/pnas.74.10.4681.
Abstract
Nerve growth factor produces a rapid increase in the activity of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) in superior cervical ganglia of young rats in vivo and in vitro. Maximum activity occurs 6-7 hr after the addition of nerve growth factor. The nerve growth factor-mediated increase in ornithine decarboxylase activity in vitro can be prevented by the addition of cycloheximide, actinomycin D, or antibody to nerve growth factor. A number of other agents were tested for their ability to increase ornithine decarboxylase were tested for their ability to increase ornithine decarboxylase activity in the ganglia; only nerve growth factor, and, to a slight extent, insulin were able to raise the activity of the enzyme. High concentrations of dibutyryl cyclic AMP (10 mM) were able to mimic the effect of nerve growth factor.
摘要
神经生长因子在体内和体外均可使幼鼠颈上神经节中的鸟氨酸脱羧酶（L-鸟氨酸羧基裂解酶，EC 4.1.1.17）的活性迅速升高。在添加神经生长因子后6-7小时出现最大活性。体外实验中，添加环己酰亚胺、放线菌素D或神经生长因子抗体可阻止神经生长因子介导的鸟氨酸脱羧酶活性增加。测试了许多其他试剂增加神经节中鸟氨酸脱羧酶活性的能力；只有神经生长因子以及在一定程度上胰岛素能够提高该酶的活性。高浓度的二丁酰环磷腺苷（10 mM）能够模拟神经生长因子的作用。
相似文献
1
Nerve growth factor increases activity of ornithine decarboxylase in superior cervical ganglia of young rats.神经生长因子可增加幼鼠颈上神经节中鸟氨酸脱羧酶的活性。
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4681-4. doi: 10.1073/pnas.74.10.4681.
2
Retrogradely transported nerve growth factor increases ornithine decarboxylase activity in rat superior cervical ganglia.逆向运输的神经生长因子可增加大鼠颈上神经节中的鸟氨酸脱羧酶活性。
Brain Res. 1980 Oct 27;200(1):39-45. doi: 10.1016/0006-8993(80)91092-6.
3
Induction of ornithine decarboxylase by renin-free nerve growth factor.无肾素神经生长因子对鸟氨酸脱羧酶的诱导作用。
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4607-9. doi: 10.1073/pnas.77.8.4607.
4
Regulation of adrenal ornithine decarboxylase by adrenocorticotropic hormone and cyclic AMP.促肾上腺皮质激素和环磷酸腺苷对肾上腺鸟氨酸脱羧酶的调节
J Clin Invest. 1973 Aug;52(8):2007-15. doi: 10.1172/JCI107385.
5
Hormonal control of ornithine decarboxylase in isolated liver cells and the effect of ethanol oxidation.离体肝细胞中鸟氨酸脱羧酶的激素调控及乙醇氧化的影响
Biochim Biophys Acta. 1979 Nov 1;587(4):556-66. doi: 10.1016/0304-4165(79)90008-4.
6
Regulation of ornithine decarboxylase activity by cyclic AMP in guinea pig lymphocytes: transcriptional and post-transcriptional control.环磷酸腺苷对豚鼠淋巴细胞中鸟氨酸脱羧酶活性的调节：转录和转录后控制
Biochim Biophys Acta. 1982 Feb 26;696(2):171-8. doi: 10.1016/0167-4781(82)90025-2.
7
The mechanism of ACTH stimulation of adrenal ornithine decarboxylase activity.促肾上腺皮质激素刺激肾上腺鸟氨酸脱羧酶活性的机制。
Endocrinology. 1975 Jul;97(1):136-44. doi: 10.1210/endo-97-1-136.
8
Cyclic AMP-dependent protein kinase mediates a cyclic AMP-stimulated decrease in ornithine and S-adenosylmethionine decarboxylase activities.环磷酸腺苷依赖性蛋白激酶介导环磷酸腺苷刺激的鸟氨酸和S-腺苷甲硫氨酸脱羧酶活性降低。
Proc Natl Acad Sci U S A. 1978 Feb;75(2):862-5. doi: 10.1073/pnas.75.2.862.
9
Is cyclic AMP the regulator of hepatic ornithine decarboxylase activity?环磷酸腺苷是肝脏鸟氨酸脱羧酶活性的调节因子吗？
Endocr Res Commun. 1977;4(6):329-41. doi: 10.3109/07435807709073626.
10
Effects of various kinds of stimulation on ornithine decarboxylase activity in superior cervical sympathetic and nodose ganglia of rats.各种刺激对大鼠颈上交感神经节和结状神经节中鸟氨酸脱羧酶活性的影响。
Cell Mol Neurobiol. 1984 Mar;4(1):79-90. doi: 10.1007/BF00710944.
引用本文的文献
1
Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor.由多胺修饰的翻译起始因子eIF5A介导的神经元生长与存活。
Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4194-9. doi: 10.1073/pnas.0611609104. Epub 2007 Feb 28.
2
Nerve growth factor increases activity of ornithine decarboxylase in rat brain.神经生长因子可增加大鼠大脑中鸟氨酸脱羧酶的活性。
Proc Natl Acad Sci U S A. 1978 Feb;75(2):1021-3. doi: 10.1073/pnas.75.2.1021.
3
Induction of ornithine decarboxylase by renin-free nerve growth factor.无肾素神经生长因子对鸟氨酸脱羧酶的诱导作用。
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4607-9. doi: 10.1073/pnas.77.8.4607.
4
The mouse submaxillary gland: a model for the study of hormonally dependent growth factors.小鼠颌下腺：一种用于研究激素依赖性生长因子的模型。
J Endocrinol Invest. 1982 May-Jun;5(3):183-96. doi: 10.1007/BF03349477.
5
Nerve growth factor rapidly induces ornithine decarboxylase mRNA in PC12 rat pheochromocytoma cells.神经生长因子可迅速诱导PC12大鼠嗜铬细胞瘤细胞中的鸟氨酸脱羧酶信使核糖核酸。
Proc Natl Acad Sci U S A. 1985 Sep;82(17):5761-5. doi: 10.1073/pnas.82.17.5761.
6
A method for the quantitative analysis of nerve growth in vitro.一种体外神经生长定量分析方法。
In Vitro Cell Dev Biol. 1988 Mar;24(3):205-10. doi: 10.1007/BF02623548.
7
PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor.具有低亲和力而非高亲和力神经生长因子受体的PC12细胞突变体既不响应神经生长因子，也不会使其内化。
J Cell Biol. 1986 Mar;102(3):830-43. doi: 10.1083/jcb.102.3.830.
8
Induction of nerve growth factor receptors on cultured human melanocytes.培养的人黑素细胞上神经生长因子受体的诱导
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5282-6. doi: 10.1073/pnas.85.14.5282.
9
Involvement of cytoskeletal structures in nerve-growth-factor-mediated induction of ornithine decarboxylase.细胞骨架结构参与神经生长因子介导的鸟氨酸脱羧酶诱导过程。
Biochem J. 1979 Jan 15;178(1):245-8. doi: 10.1042/bj1780245.
10
Intraventricular administration of nerve growth factor induces ornithine decarboxylase in peripheral tissues of the rat.脑室内注射神经生长因子可诱导大鼠外周组织中的鸟氨酸脱羧酶。
Proc Natl Acad Sci U S A. 1978 May;75(5):2512-5. doi: 10.1073/pnas.75.5.2512.
本文引用的文献
1
Differences in sensitivity to nerve growth factor of axon formation and tyrosine hydroxylase induction in cultured sympathetic neurons.培养的交感神经元中轴突形成和酪氨酸羟化酶诱导对神经生长因子敏感性的差异。
Neuroscience. 1976 Dec;1(6):489-96. doi: 10.1016/0306-4522(76)90101-9.
2
On the purification of L-ornithine decarboxylase from rat prostate and effects of thiol compounds on the enzyme.大鼠前列腺L-鸟氨酸脱羧酶的纯化及硫醇化合物对该酶的影响
J Biol Chem. 1971 Mar 25;246(6):1725-32.
3
The nerve growth factor: its mode of action on sensory and sympathetic nerve cells.神经生长因子：其对感觉神经细胞和交感神经细胞的作用方式。
Harvey Lect. 1966;60:217-59.
4
Selective induction by nerve growth factor of tyrosine hydroxylase and dopamine- -hydroxylase in the rat superior cervical ganglia.神经生长因子对大鼠颈上神经节中酪氨酸羟化酶和多巴胺-β-羟化酶的选择性诱导作用。
Proc Natl Acad Sci U S A. 1971 Jul;68(7):1598-602. doi: 10.1073/pnas.68.7.1598.
5
The nerve growth factor: purification as a 30,000-molecular-weight protein.神经生长因子：作为一种分子量为30,000的蛋白质的纯化。
Proc Natl Acad Sci U S A. 1969 Oct;64(2):787-94. doi: 10.1073/pnas.64.2.787.
6
Nerve growth factor.神经生长因子
Physiol Rev. 1968 Jul;48(3):534-69. doi: 10.1152/physrev.1968.48.3.534.
7
Effect of cyclic nucleotides on activity of cyclic 3',5'-adenosine monophosphate phosphodiesterase.环核苷酸对3',5'-环磷酸腺苷磷酸二酯酶活性的影响。
Biochem Pharmacol. 1973 Jan 15;22(2):221-8. doi: 10.1016/0006-2952(73)90275-x.
8
Purification of nerve growth factor antibodies by affinity chromatography.通过亲和层析法纯化神经生长因子抗体。
J Neurochem. 1976 Jun;26(6):1207-11. doi: 10.1111/j.1471-4159.1976.tb07008.x.
9
1,4-Diaminobutane (putrescine), spermidine, and spermine.1,4 - 二氨基丁烷（腐胺）、亚精胺和精胺。
Annu Rev Biochem. 1976;45:285-306. doi: 10.1146/annurev.bi.45.070176.001441.
10
Proposed model of major sequential biochemical events of a trophic response.营养反应主要连续生化事件的拟议模型。
Life Sci. 1976 Nov 1;19(9):1297-305.
Zotero 插件