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β-肾上腺素能受体阻断药对血浆容量的影响。肾素和醛固酮作为其降压作用的组成部分。

Effects of beta-adrenoreceptor blocking drugs on plasma volume. Renin and aldosterone as components of their antihypertensive action.

作者信息

Gordon R D

出版信息

Drugs. 1976;11 SUPPL 1:156-63. doi: 10.2165/00003495-197600111-00032.

DOI:10.2165/00003495-197600111-00032
PMID:6248
Abstract

In young males with essential hypertension, propranolol and pindolol in small doses caused significant expansion of plasma volume (PV) after one month which did not prevent a reduction in BP. With higher doses, changes in PV were inconsistent and reductions in plasma renin activity (PRA) and 24-hour aldosterone excretion (AE) not closely related to BP changes. The effects of beta-adrenoreceptor blocking drugs on PV, PRA, and AE do not appear to be important components of their anti-hypertensive action.

摘要

在患有原发性高血压的年轻男性中，小剂量的普萘洛尔和吲哚洛尔在一个月后导致血浆容量（PV）显著增加，但这并未阻止血压降低。使用较高剂量时，PV的变化不一致，血浆肾素活性（PRA）和24小时醛固酮排泄量（AE）的降低与血压变化没有密切关系。β-肾上腺素能受体阻断药物对PV、PRA和AE的影响似乎不是其抗高血压作用的重要组成部分。

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The second Lilly Prize Lecture, University of Newcastle, July 1977. beta-Adrenergic receptor blockade in hypertension, past, present and future.

本文引用的文献

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Measurement of aldosterone in peripheral blood of man and sheep.
J Clin Endocrinol Metab. 1967 Oct;27(10):1470-86. doi: 10.1210/jcem-27-10-1470.
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Time related aspects of arterial blood pressure, plasma volume, and electrolyte homeostasis in man.人体动脉血压、血浆容量和电解质稳态与时间相关的方面。
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Plasma volume and extracellular fluid volume during long-term treatment with propranolol in essential hypertension.普萘洛尔长期治疗原发性高血压期间的血浆容量和细胞外液容量
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Plasma volume changes with long-term beta-adrenergic blockade.长期β-肾上腺素能阻滞剂治疗会导致血浆容量变化。
Am Heart J. 1971 Dec;82(6):770-6. doi: 10.1016/0002-8703(71)90198-0.
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Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects.一种用于血管紧张素I的放射免疫测定法在正常人体血浆肾素活性生理测量中的应用。
J Clin Endocrinol Metab. 1969 Oct;29(10):1349-55. doi: 10.1210/jcem-29-10-1349.
6
Beta-adrenergic blockade in diuretic-treated patients with essential hypertension.利尿剂治疗的原发性高血压患者中的β-肾上腺素能阻滞剂
N Engl J Med. 1975 Jan 9;292(2):66-70. doi: 10.1056/NEJM197501092920203.