Chemtob S, Gibb W, Bard H
Biol Neonate. 1980;38(1-2):36-9. doi: 10.1159/000241325.
To investigate a possible mechanism involved in the regulation of 2,3-diphosphoglycerate (2,3-DPG) synthesis, 2,3-DPG mutase (DPGM) was measured in different mammals presenting large differences in 2,3-DPG concentration between fetal, neonatal and adult life to see the activity of this enzyme, necessary for 2,3-DPG synthesis, was related to the levels of 2,3-DPG. The data demonstrated that the minimal levels of 2,3-DPG in the adult sheep are likely due to the very low levels of DPGM. Also these findings show that the increases in 2,3-DPG levels, found in the newborn sheep during the 1st week of life, in adult rabbit and guinea pig when compared with their fetuses, are not due to an increase in levels of the DPGM.
为了研究参与2,3-二磷酸甘油酸（2,3-DPG）合成调节的可能机制，我们检测了不同哺乳动物中2,3-DPG变位酶（DPGM）的活性，这些哺乳动物在胎儿期、新生儿期和成年期的2,3-DPG浓度存在很大差异，以观察这种对2,3-DPG合成所必需的酶的活性是否与2,3-DPG水平相关。数据表明，成年绵羊中2,3-DPG的最低水平可能是由于DPGM水平极低所致。这些发现还表明，新生绵羊出生后第一周、成年兔和豚鼠与胎儿相比2,3-DPG水平的升高，并非由于DPGM水平的增加。
