Snïtyns'kyĭ V V, Antoniak H L, Bershads'kyĭ V I
Ukr Biokhim Zh (1978). 1994 Sep-Oct;66(5):31-5.
The age changes of 2,3-DPG concentration, 2,3-diphosphoglycerate mutase, hexokinase and pyruvate kinase activities in pigs erythroid cells during the first 10 days after birth have been investigated for study of the mechanism of blood oxygen-transport function regulation at the early stages of postnatal adaptation. It was established, that there are age peculiarities in young, mature and old erythrocytes metabolism in piglets during the transition to postnatal development. It was shown that the rise of 2,3-DPG, the allosteric effector of hemoglobin oxygen affinity level, is due to the increased activities of 2,3-diphosphoglycerate mutase and hexokinase after birth, that is particularly characteristic of the young pigs erythrocytes.
为研究仔猪出生后早期适应阶段血液氧运输功能调节机制,对出生后前10天猪红细胞中2,3 - 二磷酸甘油酸(2,3-DPG)浓度、2,3 - 二磷酸甘油酸变位酶、己糖激酶和丙酮酸激酶活性的年龄变化进行了研究。结果表明,仔猪在向出生后发育过渡期间,幼龄、成熟和老龄红细胞代谢存在年龄特点。研究发现,血红蛋白氧亲和力水平的变构效应剂2,3-DPG的升高是由于出生后2,3 - 二磷酸甘油酸变位酶和己糖激酶活性增加所致,这在幼猪红细胞中尤为明显。