Martin P, Vives P
Curr Med Res Opin. 1980;6(8):518-22. doi: 10.1185/03007998009109480.
A study was carried out in 49 recent cerebrovascular accident (CVA) patients to compare red cell deformability in this group with that in 65 healthy controls. Deformability was determined using a standard technique for measuring blood filtration time through a micropore filter. Filtration time was shown to be significantly reduced in the CVA patients. All patients had ACTH treatment, 28 of them receiving in addition 600 mg pentoxifylline per day, either by intravenous infusion or by intramuscular injection. After 2-weeks' treatment, red cell deformability was increased in the patients treated with pentoxifylline and ACTH and was unchanged in the 21 patients receiving only ACTH (p less than 0.001). The authors discuss the role of increased red cell deformability in the clinical prognosis of the patients.
对49例近期发生脑血管意外（CVA）的患者进行了一项研究，以比较该组患者与65名健康对照者的红细胞变形性。使用一种通过微孔滤器测量血液过滤时间的标准技术来测定变形性。结果显示，CVA患者的过滤时间显著缩短。所有患者均接受促肾上腺皮质激素（ACTH）治疗，其中28例患者还通过静脉输注或肌肉注射每天额外接受600毫克己酮可可碱治疗。经过2周的治疗，接受己酮可可碱和ACTH治疗的患者红细胞变形性增加，而仅接受ACTH治疗的21例患者红细胞变形性未改变（p<0.001）。作者讨论了红细胞变形性增加在患者临床预后中的作用。
