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Increased activity of the Na-K-ATPase in red cell-ghosts of patients with Cushing's syndrome: possible significance for the pathogenesis of glucocorticoid-induced hypertension.

作者信息

Wambach G, Helber A, Allolio B, Winkelmann W, Kaufmann W

出版信息

Klin Wochenschr. 1980 May 2;58(9):485-7. doi: 10.1007/BF01476805.

DOI:10.1007/BF01476805
PMID:6248683
Abstract

The Na-K-ATPase activity of erythrocyte ghosts was increased in 6 patients with Cushing's syndrome compared with 28 control subjects (0.986 +/- 0.291 versus 0.259 +/- 0.1 microM Pi . h-1 . mg-1, p less than 0.001). Ouabain insensitive Mg-ATPase activity was similar in both groups. These data support the concept of an activation of the Na-pump in patients with glucocorticoid excess.

摘要

相似文献

1
Increased activity of the Na-K-ATPase in red cell-ghosts of patients with Cushing's syndrome: possible significance for the pathogenesis of glucocorticoid-induced hypertension.
Klin Wochenschr. 1980 May 2;58(9):485-7. doi: 10.1007/BF01476805.
2
Sodium-potassium-dependent ATPase activity in erythrocyte ghosts of patients with primary and secondary hypertension.原发性和继发性高血压患者红细胞影中钠钾依赖型ATP酶活性
Clin Sci (Lond). 1980 Dec;59 Suppl 6:183s-185s. doi: 10.1042/cs059183s.
3
Na-K-ATPase in erythrocyte ghosts is not a marker for primary hypertension.红细胞血影中的钠钾ATP酶并非原发性高血压的标志物。
Clin Exp Hypertens (1978). 1981;3(4):663-73. doi: 10.3109/10641968109033692.
4
Na-K pump activity in erythrocytes of patients with endogenous and exogenous glucocorticoid excess.内源性和外源性糖皮质激素过多患者红细胞中的钠钾泵活性。
Cardiology. 1985;72 Suppl 1:95-8. doi: 10.1159/000173952.
5
[The activity and properties of Na,K-ATPase in the erythrocytes and the Na-pump inhibitor in the plasma of subjects with borderline arterial hypertension].[临界高血压患者红细胞中钠钾ATP酶的活性和特性以及血浆中钠泵抑制剂]
Fiziol Zh SSSR Im I M Sechenova. 1991 Sep;77(9):232-7.
6
Glucocorticoid-induced alterations in the sodium potassium pump of the human erythrocyte.糖皮质激素诱导的人红细胞钠钾泵变化
J Clin Invest. 1981 Aug;68(2):422-30. doi: 10.1172/jci110271.
7
Endogenous natriuretic factors: atrial natriuretic hormone and digitalis-like substance in Cushing's syndrome.内源性利钠因子：库欣综合征中的心房利钠激素和类洋地黄物质。
J Endocrinol. 1991 Jun;129(3):453-8. doi: 10.1677/joe.0.1290453.
8
Some properties of erythrocyte Na+-K+-ATPase in essential hypertension.
Clin Exp Hypertens A. 1987;9(7):1221-32. doi: 10.3109/10641968709160045.
9
Na+ + K+ ATPase of erythrocyte membranes in Duchenne muscular dystrophy.杜兴氏肌营养不良症患者红细胞膜上的钠钾ATP酶
Neurology. 1981 Mar;31(3):293-7. doi: 10.1212/wnl.31.3.293.
10
[Sodium-potassium-adenosine triphosphatase-activity in red cell ghosts of patients with essential hypertension (author's transl)].
Klin Wochenschr. 1979 Feb 15;57(4):169-72. doi: 10.1007/BF01477404.

本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Regulation of the (Na+ + K+)-activated ATP hydrolyzing enzyme system in rat kidney. I. The effect of adrenalectomy and the supply of sodium on the enzyme system.大鼠肾脏中（钠+钾）激活的ATP水解酶系统的调节。I. 肾上腺切除术及钠供应对该酶系统的影响。
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Effects of thyroid status on electrolyte distribution in rat tissues.
Am J Physiol. 1973 Nov;225(5):1172-7. doi: 10.1152/ajplegacy.1973.225.5.1172.
6
The role of sodium-potassium-activated adenosine triphosphatase in the reabsorption of sodium by the kidney.钠钾激活的三磷酸腺苷酶在肾脏重吸收钠中的作用。
J Clin Invest. 1967 Dec;46(12):1999-2011. doi: 10.1172/JCI105689.
7
Separate effects of aldosterone, DOCA, and methylprednisolone on renal Na-K-ATPase,醛固酮、去氧皮质酮和甲泼尼龙对肾钠钾ATP酶的单独作用
Am J Physiol. 1974 Aug;227(2):345-50. doi: 10.1152/ajplegacy.1974.227.2.345.
8
Antibodies to pig kidney (Na + +K + )-ATPase inhibit the Na + pump in human red cells provided they have access to the inner surface of the cell membrane.针对猪肾（Na⁺+K⁺）-ATP酶的抗体，只要能接触到细胞膜内表面，就能抑制人红细胞中的钠泵。
Biochim Biophys Acta. 1973 Feb 16;291(3):795-800. doi: 10.1016/0005-2736(73)90484-7.
9
Sensitivity of Na K adenosine triphosphatase activity in various structures of the rat nephron: studies with adrenalectomy.大鼠肾单位各结构中钠钾三磷酸腺苷酶活性的敏感性：肾上腺切除术研究
Eur J Clin Invest. 1971 May;1(5):307-12. doi: 10.1111/j.1365-2362.1971.tb00636.x.
10
Plasma cell membranes of the rat kidney. II. ATPase activities in adrenalectomized rats with and without steroid hormone substitution.
Pflugers Arch. 1971;324(1):26-42. doi: 10.1007/BF00587794.