Lewis A M, Cook J L
Proc Natl Acad Sci U S A. 1980 May;77(5):2886-9. doi: 10.1073/pnas.77.5.2886.
LSH Syrian hamster cells transformed in vitro by simian virus 40, which is oncogenic for hamsters, are resistant to rejection by adult allogeneic CB hamsters. In contrast, simian virus 40-transformed cells from other species are usually not oncogenic in immunocompetent autologous or isologous hosts. The ability of simian virus 40 to convey resistance to an allograft-type host response to transformed hamster cells may be important in determining the tumor-inducing capacity of these cells and could, in part, explain the species-specific oncogenicity of this virus.
经对仓鼠具有致癌性的猿猴病毒40在体外转化的叙利亚仓鼠细胞,对成年同种异体CB仓鼠的排斥具有抗性。相比之下,来自其他物种的猿猴病毒40转化细胞在具有免疫活性的自体或同基因宿主中通常不具有致癌性。猿猴病毒40赋予转化仓鼠细胞对同种异体移植型宿主反应的抗性的能力,在确定这些细胞的致瘤能力方面可能很重要,并且在一定程度上可以解释这种病毒的物种特异性致癌性。