Kuklin V V, Iustratova L S, Zhdanov V G
Antibiotiki. 1980 Jun;25(6):403-7.
Spontaneous and nitrosomethylbiuret-induced prototrophic revertants of various biochemical mutants of Str. griseus producing grisin, a streptothricin antibiotic, were isolated. The antibiotic production level of the revertants was studied. It was found that most of the prototrophic revertants synthesized much higher amounts of grisin than the initial biochemical mutants. It was also shown that a number of the prototrophic revertants of the methionine- and arginine-dependent mutants synthesized 20-23% higher amounts of grisin as compared to the control.
分离出了产生链丝菌素类抗生素grisin的灰色链霉菌各种生化突变体的自发和亚硝基甲基缩二脲诱导的原养型回复突变体。对回复突变体的抗生素生产水平进行了研究。发现大多数原养型回复突变体合成的grisin量比初始生化突变体高得多。还表明，与对照相比，一些甲硫氨酸和精氨酸依赖型突变体的原养型回复突变体合成的grisin量高20-23%。
