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5,8,11,14,17-二十碳五烯酸在人血小板中的转化

Transformations of 5,8,11,14,17-eicosapentaenoic acid in human platelets.

作者信息

Hamberg M

出版信息

Biochim Biophys Acta. 1980 Jun 23;618(3):389-98. doi: 10.1016/0005-2760(80)90257-x.

DOI:10.1016/0005-2760(80)90257-x
PMID:6249377
Abstract

5,8,11,14,17-[1-14C]Eicosapentaenoic acid was prepared biosynthetically from [1-14C]arachidonic acid using the fungus, Saprolegnia parasitica. Incubation of 5,8,11,14,17-[1-14C]eicosapentaenoic acid with suspensions of human platelets led to the formation of three labeled compounds which were identified as thromboxane B3 (2-5% yield), 12-hydroxy-5,8,10,14-heptadecatetraenoic acid (2-5% yield), and 12-hydroxy-5,8,10,14,17-eicosapentaenoic acid (7-59% yield).

摘要

使用寄生水霉真菌，以[1-¹⁴C]花生四烯酸为原料通过生物合成法制备了5,8,11,14,17-[1-¹⁴C]二十碳五烯酸。将5,8,11,14,17-[1-¹⁴C]二十碳五烯酸与人血小板悬液一起孵育，生成了三种标记化合物，分别鉴定为血栓素B3（产率2 - 5%）、12-羟基-5,8,10,14-十七碳四烯酸（产率2 - 5%）和12-羟基-5,8,10,14,17-二十碳五烯酸（产率7 - 59%）。

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Transformations of 5,8,11,14,17-eicosapentaenoic acid in human platelets.5,8,11,14,17-二十碳五烯酸在人血小板中的转化
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