Bedikian A Y, Valdivieso M, Maroun J, Gutterman J U, Hersh E M, Bodey G P
Cancer. 1980 Aug 1;46(3):463-7. doi: 10.1002/1097-0142(19800801)46:3<463::aid-cncr2820460307>3.0.co;2-p.
Vindesine, a derivative of vinblastine, was administered to 39 patients with advanced colorectal cancer refractory to 5-fluorouracil alone or in combination with other chemotherapeutic agents. The initial dose of vindesine was 4 mg/m2 administered intravenously (IV) over 30 minutes every two weeks. Tumor regression of more than 50% was seen in 2 and stable disease in 13 of 33 patients evaluable for response. Prior treatment with vincristine did not seem to influence response to vindesine. The median survival time was four months. The major toxic effect of vindesine was peripheral neuropathy, which occurred in 35% of patients who received two or more courses of treatment. Methanol extract residue of BCG (MER) was administered IV to 20 of 39 patients receiving vindesine without randomization in order to evaluate toxicities associated with IV MER. The most common toxic reactions to MER were fever and chills, while malaise and headaches were less common. Transient respiratory distress associated with appearance of reticulonodular pulmonary infiltrates occurred in 1 patient. Thus, MER at a dose of less than 1 mg/m2 did not seem to significantly influence the response rate to vindesine or the survival of patients. However, it appeared to ameliorate the myelosuppression caused by vindesine.
长春地辛是长春碱的衍生物，对39例单用5-氟尿嘧啶或联合其他化疗药物治疗无效的晚期结直肠癌患者进行了治疗。长春地辛的初始剂量为4mg/m²，每两周静脉注射（IV）30分钟。在可评估反应的33例患者中，2例出现超过50%的肿瘤消退，13例病情稳定。先前使用长春新碱治疗似乎不影响对长春地辛的反应。中位生存时间为4个月。长春地辛的主要毒性作用是周围神经病变，在接受两个或更多疗程治疗的患者中，35%出现该症状。为了评估与静脉注射卡介苗甲醇提取物残渣（MER）相关的毒性，在未进行随机分组的情况下，对39例接受长春地辛治疗的患者中的20例静脉注射了MER。对MER最常见的毒性反应是发热和寒战，而不适和头痛则较少见。1例患者出现与网状结节状肺浸润相关的短暂呼吸窘迫。因此，剂量小于1mg/m²的MER似乎不会显著影响长春地辛的反应率或患者的生存率。然而，它似乎改善了长春地辛引起的骨髓抑制。
