Acker H
Fed Proc. 1980 Jul;39(9):2641-7.
The paper concentrates on measurements of tissue pO2 and local flow, which are both assumed to determine the nervous signal of the carotid body. The measurements were performed with needle electrodes. Inside the specific tissue of the carotid bodies of cat and rabbit, which is assumed to be surrounded by an oxygen barrier, pO2 values between 7 and 25 torr were recorded. From experiments on the fetal carotid body it was concluded that these low values are essential for the chemoreceptive process. Two types of blood flow were observed in the carotid body: high flow running through arteriovenous shunt vessels or flow-through channels (total flow), and low flow running through the capillaries supplying the specific tissue (local flow). Local flow decreases under hypoxia, whereas total flow follows the changes in blood pressure in any case. These pO2-dependent regulatory mechanisms influence the extracellular calcium activity, which determines the calcium uptake of type I cells under hypoxia and, consequently, (by vesicle release) the chemoreceptor discharge. Other mechanisms are assumed to be involved during hypercapnia, since under these conditions local flow does not change.
该论文主要关注组织氧分压和局部血流的测量，二者均被认为可决定颈动脉体的神经信号。测量是使用针电极进行的。在猫和兔的颈动脉体特定组织内部（该组织被认为被氧屏障包围），记录到的氧分压值在7至25托之间。通过对胎儿颈动脉体的实验得出结论，这些低值对于化学感受过程至关重要。在颈动脉体中观察到两种类型的血流：通过动静脉分流血管或流通通道的高血流（总血流），以及通过为特定组织供血的毛细血管的低血流（局部血流）。低氧时局部血流减少，而总血流在任何情况下都随血压变化。这些依赖于氧分压的调节机制影响细胞外钙活性，细胞外钙活性决定低氧时I型细胞的钙摄取，进而（通过囊泡释放）决定化学感受器放电。假设在高碳酸血症期间还涉及其他机制，因为在这些条件下局部血流不变。
