Berner B, Blanco C E, Ellison G W, Myers L W, Hirsch H E
J Neurosci Res. 1980;5(3):225-31. doi: 10.1002/jnr.490050307.
Electron spin resonance (ESR) was used in a search for a possible generalized membrane defect underlying myelin instability in multiple sclerosis (MS). In contrast to most ESR studies of biological membranes, a small, nonelectrolyte spin label, TEMPO, was chosen; its partition coefficient was determined in extracted erythrocyte lipids from MS patients and normal controls. No differences were observed the advantages and limitations of TEMPO in comparison with lipid spin labels as probes for the study of biological membranes are discussed.
电子自旋共振（ESR）被用于探寻多发性硬化症（MS）中髓鞘不稳定背后可能存在的普遍膜缺陷。与大多数关于生物膜的ESR研究不同，选用了一种小型非电解质自旋标记物TEMPO；测定了其在从MS患者和正常对照者提取的红细胞脂质中的分配系数。未观察到差异，并讨论了TEMPO与脂质自旋标记物相比作为生物膜研究探针的优缺点。
