大鼠肾乳头组织成分的不稳定性
Lability of renal papillary tissue composition in the rat.
作者信息
Atherton J C
出版信息
J Physiol. 1978 Jan;274:323-8. doi: 10.1113/jphysiol.1978.sp012150.
Abstract
- The acute effects of (a) a minor operative procedure using ether as the anaesthetic, and (b) the administration of 0.9% saline as a single I.V. injection in the conscious rat, on renal tissue composition were studied in hydropenic and normally hydrated rats. 2. The operative procedure and anaesthesia induced a rapid and transient decrease in papillary osmolality in both hydropenic and normally hydrated animals, the important contributing factor being a significant decrease in urea content. 3. Administration of a small volume of saline caused a rapid decrease in urea content, and an increase in water content. 4. It is concluded that papillary composition is extremely labile, large changes being produced by relatively minor experimental procedures.
摘要
- 在缺水和正常水合的大鼠中，研究了（a）使用乙醚作为麻醉剂的小型手术操作，以及（b）在清醒大鼠中单次静脉注射0.9%生理盐水对肾组织成分的急性影响。2. 手术操作和麻醉在缺水和正常水合的动物中均引起乳头渗透压迅速且短暂的降低，重要的促成因素是尿素含量显著降低。3. 注射少量生理盐水导致尿素含量迅速降低，水分含量增加。4. 得出的结论是，乳头成分极其不稳定，相对较小的实验操作就能产生巨大变化。
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本文引用的文献
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Effect of anaesthetics and haemorrhage on the release of neurohypophysial antidiuretic hormone.麻醉和出血对神经垂体抗利尿激素释放的影响。
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8
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10
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J Physiol. 1971 Mar;213(2):291-309. doi: 10.1113/jphysiol.1971.sp009383.
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