水合作用变化和溶质排泄对赖氨酸加压素输注对清醒大鼠尿液及肾组织成分影响的作用

Influence of variations in hydration and in solute excretion of the effects of lysine-vasopressin infusion on urinary and renal tissue composition in the conscious rat.

Atherton J C, Evans J A, Green R, Thomas S

J Physiol. 1971 Mar;213(2):311-27. doi: 10.1113/jphysiol.1971.sp009384.

Abstract

The changes in urinary and renal tissue composition induced by continuous, intravenous infusion of lysine-vasopressin (60 mu-u./min. 100 g body wt. until steady-state conditions prevailed) in normally hydrated, hydropaenic, saline-loaded (0.9%, w/v) and mannitol-loaded (15%, w/v) rats were determined and compared with those induced in water-loaded rats.2. Previous reports that the urinary responses to antidiuretic hormones vary both with hydration status and with concurrent solute excretion rate were confirmed.3. The data show that variations in urinary responses were accompanied by differences in the papillary responses to lysine-vasopressin.4. The results are discussed in terms of the effects of hydration and concurrent solute excretion on factors influencing (a) medullary accumulation of water and solute, (b) osmotic water reabsorption and (c) osmotic equilibration across the collecting duct; and of the effects of lysine-vasopressin on these factors.5. It is concluded that the effects of hydration and solute excretion on the antidiuretic responses to lysine-vasopressin may be interpreted by differences in (a) the medullary composition prevailing at the start and (b) any further changes in medullary composition that can be induced under the experimental circumstances.

摘要

测定了在正常水合、水缺乏、生理盐水负荷（0.9%，w/v）和甘露醇负荷（15%，w/v）的大鼠中，通过持续静脉输注赖氨酸加压素（60微单位/分钟·100克体重，直至达到稳态）所引起的尿液和肾组织成分变化，并与水负荷大鼠中的变化进行比较。
先前关于抗利尿激素的尿液反应随水合状态和同时的溶质排泄率而变化的报道得到了证实。
数据表明，尿液反应的变化伴随着对赖氨酸加压素的乳头反应的差异。
根据水合和同时溶质排泄对影响（a）髓质中水和溶质的积聚、（b）渗透性水重吸收以及（c）集合管的渗透平衡的因素的影响，以及赖氨酸加压素对这些因素的影响，对结果进行了讨论。
得出的结论是，水合和溶质排泄对赖氨酸加压素抗利尿反应的影响可以通过（a）开始时存在的髓质成分差异以及（b）在实验条件下可诱导的髓质成分的任何进一步变化来解释。