醛固酮对肾脏代谢的影响。
Aldosterone effects on renal metabolism.
作者信息
Snart R S, Taylor E
出版信息
J Physiol. 1978 Jan;274:447-54. doi: 10.1113/jphysiol.1978.sp012159.
Abstract
- Manometric studies of the sodium dependent oxygen consumption in rat kidney slices have failed to reveal any significant effect of aldosterone treatment, adrenalectomy or sodium diet on sodium diet on sodium metabolism. 2. However, ammonia release from kidney slices was significantly reduced following adrenalectomy and this decrease was influenced by aldosterone treatment. 3. The dose-response characteristic obtained for this aldosterone-stimulated ammonia release has been determined. 4. The effect of a high Na+ diet on the ammonia release has been studied. An initial decrease after 2 days may be associated with decreased endogenous aldosterone secretion. However, aldosterone (2.5 microgram/100 g body weight)injections into these high Na+ treated animals fails to restore the normal ammonia release. 5. The effects of aldosterone (2.5 microgram/100 g body weight), dexamethasone (2.5 microgram/100 g body weight) and corticosterone (2.5 microgram/100 g body weight) injections, in adrenalectomized rats, on ammonia release and tissue tyrosine aminotransferase activities have been compared.
摘要
- 对大鼠肾切片中钠依赖性氧消耗的测压研究未能揭示醛固酮治疗、肾上腺切除术或钠饮食对钠代谢的任何显著影响。2. 然而，肾上腺切除术后肾切片中的氨释放显著减少，且这种减少受醛固酮治疗的影响。3. 已确定了这种醛固酮刺激的氨释放的剂量反应特征。4. 研究了高钠饮食对氨释放的影响。2天后的初始下降可能与内源性醛固酮分泌减少有关。然而，向这些高钠处理的动物注射醛固酮（2.5微克/100克体重）未能恢复正常的氨释放。5. 比较了在肾上腺切除的大鼠中注射醛固酮（2.5微克/100克体重）、地塞米松（2.5微克/100克体重）和皮质酮（2.5微克/100克体重）对氨释放和组织酪氨酸转氨酶活性的影响。
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