逆转录病毒前病毒的序列类似于细菌转座因子的序列。

Sequence of retrovirus provirus resembles that of bacterial transposable elements.

作者信息

Shimotohno K, Mizutani S, Temin H M

出版信息

Nature. 1980 Jun 19;285(5766):550-4. doi: 10.1038/285550a0.

Abstract

The nucleotide sequences of the terminal regions of an infectious integrated retrovirus cloned in the modified lambda phage cloning vector Charon 4A have been elucidated. There is a 569-base pair direct repeat at both ends of the viral DNA. The cell-virus junctions at each end consist of a 5-base pair direct repeat of cell DNA next to a 3-base pair inverted repeat of viral DNA. This structure resembles that of a transposable element and is consistent with the protovirus hypothesis that retroviruses evolved from the cell genome.

摘要

已阐明克隆于经修饰的λ噬菌体克隆载体Charon 4A中的传染性整合逆转录病毒末端区域的核苷酸序列。病毒DNA两端存在一个569个碱基对的正向重复序列。两端的细胞-病毒连接点由细胞DNA的一个5个碱基对的正向重复序列与病毒DNA的一个3个碱基对的反向重复序列相邻组成。这种结构类似于转座元件的结构，并且与逆转录病毒从细胞基因组进化而来的原病毒假说相一致。