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新型抗菌抗生素2562成分的分离与理化研究

[Isolation and physicochemical study of the components of the new antibacterial antibiotic 2562].

作者信息

Lysenkova L N, Brazhnikova M G, Borisova V N, Fedorova G B, Rubasheva L M

出版信息

Antibiotiki. 1980 Jul;25(7):483-8.

PMID:6250459
Abstract

An antibacterial antibiotic complex consisting of 2 components designated as 2562 A and 2562 B is produced by Streptomyces griseovarabilis. The antibiotic was isolated from the mycelium and purified chromatographically on a column with aqueous silicic acid. The study of the components showed that component 2562 A was chlorbiocin, while component 2562 B differed from the known antibiotics of this group. Physicochemical assays demonstrated that component 2562 B differed from chlorbiocin by the absence of the methyl group in pyrrol, which is probably attached to sugar at beta-position. It was found that component 2562 B is a new representative of the antibiotic cumero-glycoside group.

摘要

可变灰链霉菌产生了一种由两种成分(分别命名为2562 A和2562 B)组成的抗菌抗生素复合物。该抗生素从菌丝体中分离出来,并在含水硅酸柱上进行色谱纯化。对这些成分的研究表明,成分2562 A是氯比菌素,而成分2562 B与该组已知抗生素不同。物理化学分析表明,成分2562 B与氯比菌素的区别在于吡咯中没有甲基,该甲基可能在β位与糖相连。发现成分2562 B是抗生素香豆素 - 糖苷组的一个新代表。

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