Gilbert J C, Sawas A H, Wyllie M G
Arch Int Pharmacodyn Ther. 1980 May;245(1):42-7.
The activity of Na+, K+-ATPase was determined in synaptosomes and in pellets, (containing membranes, mitochondria and vesicles) and cytoplasm prepared from synaptosomes from rat cerebral cortex. The activity of the pellets was more than two fold higher than that of the synaptosomes or of their components and adding back the cytoplasm reduced the activity of the pellets. Noradrenaline did not affect the activity of the pellets but increased that of the synaptosomes in a dose-dependent fashion. It inhibited the activity of the membranes. Results indicate that synaptosomal Na+, K+-ATPase activity is low because of a factor in the cytoplasm and this factor is not present in synaptosome pellets. NA antagonises the activity of the factor.
在从大鼠大脑皮层突触体制备的突触体、沉淀（包含膜、线粒体和囊泡）以及细胞质中测定了Na⁺, K⁺-ATP酶的活性。沉淀的活性比突触体或其组分的活性高两倍多，添加回细胞质会降低沉淀的活性。去甲肾上腺素不影响沉淀的活性，但以剂量依赖的方式增加突触体的活性。它抑制膜的活性。结果表明，突触体Na⁺, K⁺-ATP酶活性低是由于细胞质中的一个因子，而该因子不存在于突触体沉淀中。去甲肾上腺素拮抗该因子的活性。
