Levitt M, Harris C, Squire R, Wenk M, Mollelo C, Springer S
J Natl Cancer Inst. 1978 Mar;60(3):701-5. doi: 10.1093/jnci/60.3.701.
A high incidence of pancreatic duct neoplasms was induced in outbred male Syrian golden hamsters following weekly sc injection of N-nitroso-bis(2-hydroxypropyl)amine for life. The first such tumors appeared as early as 16 experimental weeks; the maximum incidence reached 100% by the termination of the study. Tumors in the respiratory tracts and angiosarcomas of the livers of the hamsters were also observed in high frequency. Latency of the induced neoplasms was significantly decreased by the substitution of distilled water for olive oil as the vehicle for the carcinogen.
通过每周皮下注射N-亚硝基双（2-羟丙基）胺直至动物生命结束，可在远交系雄性叙利亚金黄地鼠中诱发高发病率的胰腺导管肿瘤。最早在实验第16周就出现了此类肿瘤；到研究结束时，最高发病率达到了100%。在仓鼠的呼吸道和肝脏血管肉瘤中也观察到了高频率的肿瘤。用蒸馏水替代橄榄油作为致癌物的载体，可显著缩短诱发肿瘤的潜伏期。
