Ross F P, Henry H L
Clin Orthop Relat Res. 1980 Jun(149):249-67.
Many advances have been made in the past several years in our understanding of the metabolism and mechanism of action of vitamin D. Recognition of the clinical implications of this knowledge continues to grow. Despite these gains, however, many questions remain unanswered. These include the role of 24,25(OH)2D3 in physiologic processes, the nature of the contribution of vitamin D metabolism to bone growth and development, the responses of other possible target tissues such as the pancreas and parathyroid gland, and the further elucidation of interactions between vitamin D metabolites and parathyroid hormone in the maintenance of calcium and phosphorus homeostasis. The next decade of research is bound to bring insight into these and other questions.
在过去几年里，我们对维生素D的代谢及作用机制的认识取得了许多进展。对这一知识临床意义的认识也在不断加深。然而，尽管有这些进展，许多问题仍未得到解答。这些问题包括24,25(OH)2D3在生理过程中的作用、维生素D代谢对骨骼生长发育的贡献的本质、胰腺和甲状旁腺等其他可能靶组织的反应，以及进一步阐明维生素D代谢产物与甲状旁腺激素在维持钙和磷稳态中的相互作用。未来十年的研究必将为这些及其他问题带来深入见解。
