Exner G U, Prader A, Elsasser U, Rüegsegger P, Anliker M, Steendijk R
Helv Paediatr Acta. 1980 Mar;35(1):39-49.
125I-computed tomography (CT) for the bone mineral analysis of the radius was performed on 9 children with vitamin D resistant hypophosphatemic rickets (VDRR) treated with vitamin D in pharmacological doses. Trabecular bone density was increased in 1 patient and normal in all others. The cortical width of the diaphysis of the radius was decreased, and the cross sectional area of the bone increased, but the total amount of compat bone mineral in the cross section was normal. Measurements of the second metacarpal bone on X-rays of the hand revealed similar findings. Microradiographic and histological examinations of the fibula on 9 different patients also treated with vitamin D showed grossly abnormal mineralization of bone tissue with a perilacunar mineral deficit. It is concluded, that the amount of compact bone and trabecular bone is not decreased in children with VDRR. The normal mineral content determined by CT and the impaired mineralization of the bone material examined by microradiography indicate an over-abundance of incompletely mineralized bone.
对9名接受药理剂量维生素D治疗的维生素D抵抗性低磷血症佝偻病（VDRR）患儿进行了125I计算机断层扫描（CT）以分析桡骨的骨矿物质。1例患者的小梁骨密度增加，其他所有患者的小梁骨密度正常。桡骨干骺端的皮质宽度减小，骨横截面积增加，但横截面上骨矿物质总量正常。对手部X线片上的第二掌骨进行测量也得到了类似结果。对另外9名同样接受维生素D治疗的不同患者的腓骨进行微射线照相和组织学检查，结果显示骨组织矿化严重异常，存在骨陷窝周围矿物质缺乏。得出的结论是，VDRR患儿的密质骨和小梁骨数量并未减少。CT测定的正常矿物质含量以及微射线照相检查显示的骨材料矿化受损表明存在大量矿化不完全的骨。
